Assay Detail
Binding
CHEMBL930381
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Inhibition of human factor 10a
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 9.10 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402980 | — | — | 1 | 10.89 |
| CHEMBL257398 | — | — | 1 | 10.55 |
| CHEMBL260086 | — | — | 1 | 10.33 |
| CHEMBL260085 | — | — | 1 | 10.24 |
| CHEMBL257400 | — | — | 1 | 10.22 |
| CHEMBL261536 | — | — | 1 | 10.19 |
| CHEMBL231779 | APIXABAN | 4.0 | 1 | 10.10 |
| CHEMBL258196 | — | — | 1 | 9.92 |
| CHEMBL256152 | — | — | 1 | 9.85 |
| CHEMBL257399 | — | — | 1 | 9.85 |
| CHEMBL259534 | — | — | 1 | 9.85 |
| CHEMBL404448 | — | — | 1 | 9.72 |
| CHEMBL257966 | — | — | 1 | 9.68 |
| CHEMBL260369 | — | — | 1 | 9.62 |
| CHEMBL404449 | — | — | 1 | 9.48 |
| CHEMBL403075 | — | — | 1 | 9.35 |
| CHEMBL259535 | — | — | 1 | 9.24 |
| CHEMBL402836 | — | — | 1 | 9.21 |
| CHEMBL411044 | — | — | 1 | 9.00 |
| CHEMBL256573 | — | — | 1 | 8.96 |
| CHEMBL260354 | — | — | 1 | 8.92 |
| CHEMBL1162978 | — | — | 1 | 8.89 |
| CHEMBL428432 | — | — | 1 | 8.70 |
| CHEMBL258188 | — | — | 1 | 8.66 |
| CHEMBL260912 | — | — | 1 | 8.52 |
| CHEMBL257967 | — | — | 1 | 8.38 |
| CHEMBL402761 | — | — | 1 | 8.26 |
| CHEMBL260911 | — | — | 1 | 7.37 |
| CHEMBL256574 | — | — | 1 | 7.23 |
| CHEMBL259533 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402980 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL257398 | — | Ki | = | 0.028 | nM | 10.55 |
| CHEMBL260086 | — | Ki | = | 0.047 | nM | 10.33 |
| CHEMBL260085 | — | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL257400 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL261536 | — | Ki | = | 0.065 | nM | 10.19 |
| CHEMBL231779 | APIXABAN | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL258196 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL256152 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL257399 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL259534 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL404448 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL257966 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL260369 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL404449 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL403075 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL259535 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL402836 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL411044 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL256573 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL260354 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1162978 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL428432 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL258188 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL260912 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL257967 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL402761 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL260911 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL256574 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL259533 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL404745 | — | Ki | = | 7670.0 | nM | 5.12 |
| CHEMBL260160 | — | Ki | = | 0.005 | nM | - |