Assay Detail
Functional
CHEMBL930419
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Suppression of staurosporine-initiated apoptosis in human T17 cells at 0.5 uM
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T17 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.41 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444109 | GAMBOGIC AMIDE | — | 1 | 8.30 |
| CHEMBL555017 | GAMBOGIC ACID | — | 1 | 7.70 |
| CHEMBL260118 | — | — | 1 | 6.92 |
| CHEMBL260412 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444109 | GAMBOGIC AMIDE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL555017 | GAMBOGIC ACID | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL260118 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL260412 | — | EC50 | = | 200.0 | nM | 6.70 |