Compound Detail
CHEMBL444109
GAMBOGIC AMIDE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)=CCC[C@]1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)O[C@]12C(=C[C@@H]4CC1C(C)(C)O[C@@]2(C/C=C(/C)C(N)=O)C4=O)C3=O
Basic Information
| ChEMBL ID | CHEMBL444109 |
| Name | GAMBOGIC AMIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NFVXKLYWFCNBCO-JDDSCDDDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
627.8
MW (Da)
6.64
ALogP
7
HBA
2
HBD
125.2
PSA (Ų)
0.24
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 8.3 | 8.3 | 5.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 5.0 | nM | 8.3 | Suppression of staurosporine-initiated apoptosis in human T17 cells at 0.5 uM | 17911251 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17911251 | 10.1073/pnas.0706662104 | High affinity nerve growth factor receptor | 9 |
| 17911251 | 10.1073/pnas.0706662104 | Unchecked | 8 |
| 17911251 | 10.1073/pnas.0706662104 | PC-12 | 3 |
| 17911251 | 10.1073/pnas.0706662104 | BDNF/NT-3 growth factors receptor | 2 |
| 17911251 | 10.1073/pnas.0706662104 | NT-3 growth factor receptor | 2 |
| 17911251 | 10.1073/pnas.0706662104 | NON-PROTEIN TARGET | 2 |
| 17911251 | 10.1073/pnas.0706662104 | Mitogen-activated protein kinase 3 | 2 |
| 17911251 | 10.1073/pnas.0706662104 | Mitogen-activated protein kinase 1 | 2 |
| 17911251 | 10.1073/pnas.0706662104 | Mus musculus | 2 |
| 17911251 | 10.1073/pnas.0706662104 | Tumor necrosis factor receptor superfamily member 16 | 1 |
| 17911251 | 10.1073/pnas.0706662104 | Receptor tyrosine-protein kinase erbB-3 | 1 |
| 17911251 | 10.1073/pnas.0706662104 | Epidermal growth factor receptor | 1 |
| 17911251 | 10.1073/pnas.0706662104 | RAC-alpha serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine