Assay Detail
Functional
CHEMBL930438
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzoic acid derivatives, acetophenones, and anti-inflammatory constituents from Melicope semecarpifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.28 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365739 | DIPHENYLENEIODONIUM | — | 1 | 6.28 |
| CHEMBL403638 | — | — | 1 | - |
| CHEMBL255921 | — | — | 1 | - |
| CHEMBL349724 | KUMATAKENIN | — | 1 | - |
| CHEMBL165180 | PACHYPODOL | — | 1 | - |
| CHEMBL77966 | RETUSIN | — | 1 | - |
| CHEMBL258395 | — | — | 1 | - |
| CHEMBL255248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL403638 | — | IC50 | = | 6.62 | ug.mL-1 | - |
| CHEMBL255921 | — | IC50 | = | 8.02 | ug.mL-1 | - |
| CHEMBL349724 | KUMATAKENIN | IC50 | = | 1.2 | ug.mL-1 | - |
| CHEMBL165180 | PACHYPODOL | IC50 | = | 1.0 | ug.mL-1 | - |
| CHEMBL77966 | RETUSIN | IC50 | = | 1.43 | ug.mL-1 | - |
| CHEMBL258395 | — | IC50 | = | 3.75 | ug.mL-1 | - |
| CHEMBL255248 | — | IC50 | = | 0.73 | ug.mL-1 | - |