Assay Detail
Functional
CHEMBL930441
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release at 10 ug/mL
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzoic acid derivatives, acetophenones, and anti-inflammatory constituents from Melicope semecarpifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 5 | - | - |
| IC50 | 1 | 4.45 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 4.45 |
| CHEMBL255921 | — | — | 1 | - |
| CHEMBL256129 | — | — | 1 | - |
| CHEMBL267701 | — | — | 1 | - |
| CHEMBL255920 | — | — | 1 | - |
| CHEMBL254780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 35680.0 | nM | 4.45 |
| CHEMBL255921 | — | Inhibition | = | 46.11 | % | - |
| CHEMBL256129 | — | Inhibition | = | 27.35 | % | - |
| CHEMBL267701 | — | Inhibition | = | 26.62 | % | - |
| CHEMBL255920 | — | Inhibition | = | 28.73 | % | - |
| CHEMBL254780 | — | Inhibition | = | 7.48 | % | - |