Assay Detail
Functional
CHEMBL930491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assay
46
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a novel series of nonsteroidal androgen receptor modulators: 5- or 6-oxachrysen-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Efficacy | 23 | - | - |
| IC50 | 23 | 7.33 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427731 | — | — | 2 | 7.72 |
| CHEMBL253746 | — | — | 2 | 7.72 |
| CHEMBL256768 | — | — | 2 | 7.70 |
| CHEMBL258241 | — | — | 2 | 7.57 |
| CHEMBL258397 | — | — | 2 | 7.32 |
| CHEMBL253744 | — | — | 2 | 7.21 |
| CHEMBL402136 | — | — | 2 | 7.11 |
| CHEMBL258384 | — | — | 2 | 6.84 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 2 | 6.79 |
| CHEMBL27769 | STANOLONE | 2.0 | 2 | - |
| CHEMBL450933 | — | — | 2 | - |
| CHEMBL257751 | — | — | 2 | - |
| CHEMBL403219 | — | — | 2 | - |
| CHEMBL253535 | — | — | 2 | - |
| CHEMBL401629 | — | — | 2 | - |
| CHEMBL258190 | — | — | 2 | - |
| CHEMBL257151 | — | — | 2 | - |
| CHEMBL256947 | — | — | 2 | - |
| CHEMBL256977 | — | — | 2 | - |
| CHEMBL256769 | — | — | 2 | - |
| CHEMBL427898 | — | — | 2 | - |
| CHEMBL450334 | — | — | 2 | - |
| CHEMBL401711 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427731 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL253746 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL256768 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL258241 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL258397 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL253744 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL402136 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL258384 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL258384 | — | Efficacy | = | 63.0 | % | - |
| CHEMBL403219 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL450334 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27769 | STANOLONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL27769 | STANOLONE | Efficacy | < | 20.0 | % | - |
| CHEMBL450933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL450933 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL258241 | — | Efficacy | = | 57.0 | % | - |
| CHEMBL409 | BICALUTAMIDE | Efficacy | = | 85.0 | % | - |
| CHEMBL402136 | — | Efficacy | = | 68.0 | % | - |
| CHEMBL403219 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL253744 | — | Efficacy | = | 63.0 | % | - |
| CHEMBL253746 | — | Efficacy | = | 49.0 | % | - |
| CHEMBL427731 | — | Efficacy | = | 47.0 | % | - |
| CHEMBL256768 | — | Efficacy | = | 29.0 | % | - |
| CHEMBL450334 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL257751 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL257751 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL256947 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL258190 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL253535 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL258190 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL401629 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL257151 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL401629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL253535 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL258397 | — | Efficacy | = | 62.0 | % | - |
| CHEMBL257151 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL401711 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL256947 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL256977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL256977 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL256769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL256769 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL427898 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL427898 | — | Efficacy | < | 20.0 | % | - |
| CHEMBL401711 | — | IC50 | > | 10000.0 | nM | - |