Assay Detail
Binding
CHEMBL930494
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Inhibition of human NET
47
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.80 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402441 | — | — | 1 | 8.77 |
| CHEMBL427904 | — | — | 1 | 8.54 |
| CHEMBL404729 | — | — | 1 | 8.49 |
| CHEMBL256557 | — | — | 1 | 8.46 |
| CHEMBL404730 | — | — | 1 | 8.41 |
| CHEMBL258451 | — | — | 1 | 8.40 |
| CHEMBL409715 | — | — | 1 | 8.38 |
| CHEMBL260440 | — | — | 1 | 8.36 |
| CHEMBL257336 | — | — | 1 | 8.36 |
| CHEMBL404013 | — | — | 1 | 8.35 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 8.29 |
| CHEMBL405613 | — | — | 1 | 8.28 |
| CHEMBL411655 | — | — | 1 | 8.24 |
| CHEMBL260131 | — | — | 1 | 8.23 |
| CHEMBL264678 | — | — | 1 | 8.20 |
| CHEMBL264430 | — | — | 1 | 8.19 |
| CHEMBL408016 | — | — | 1 | 8.15 |
| CHEMBL259694 | — | — | 1 | 8.15 |
| CHEMBL406789 | — | — | 1 | 8.15 |
| CHEMBL408384 | — | — | 1 | 8.12 |
| CHEMBL257335 | — | — | 1 | 8.09 |
| CHEMBL410015 | — | — | 1 | 8.03 |
| CHEMBL260988 | — | — | 1 | 7.92 |
| CHEMBL260439 | — | — | 1 | 7.85 |
| CHEMBL408940 | — | — | 1 | 7.85 |
| CHEMBL260863 | — | — | 1 | 7.82 |
| CHEMBL411677 | — | — | 1 | 7.77 |
| CHEMBL258180 | — | — | 1 | 7.75 |
| CHEMBL411033 | — | — | 1 | 7.70 |
| CHEMBL403469 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402441 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL427904 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL404729 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL256557 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL404730 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL258451 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL409715 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL260440 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL257336 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL404013 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL405613 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL411655 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL260131 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL264678 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL264430 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL408016 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL259694 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL406789 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL408384 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL257335 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL410015 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL260988 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL260439 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL408940 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL260863 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL411677 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL258180 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL411033 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL403469 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL410054 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL99946 | LEVOMILNACIPRAN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL258450 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL255303 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL404145 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL259209 | MILNACIPRAN | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL410055 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL403949 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL405728 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL259209 | MILNACIPRAN | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL260335 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL257551 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410062 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL405462 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL257549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL257550 | — | IC50 | > | 10000.0 | nM | - |