Compound Detail
CHEMBL404729
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL404729 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYNDMWYYCBLSSM-HNAYVOBHSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
2.17
ALogP
4
HBA
1
HBD
64.8
PSA (Ų)
0.77
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 8.49 | 8.49 | 3.2 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 7.41 | 7.41 | 39.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 5.54 | 5.54 | 2900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | IC50 | = | 3.2 | nM | 8.49 | Inhibition of human NET | 18445525 |
| Sodium-dependent serotonin transporter | IC50 | = | 39.0 | nM | 7.41 | Inhibition of human SERT | 18445525 |
| Sodium-dependent dopamine transporter | IC50 | = | 2900.0 | nM | 5.54 | Inhibition of human DAT | 18445525 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18445525 | 10.1016/j.bmcl.2008.04.025 | Sodium-dependent noradrenaline transporter | 1 |
| 18445525 | 10.1016/j.bmcl.2008.04.025 | Sodium-dependent serotonin transporter | 1 |
| 18445525 | 10.1016/j.bmcl.2008.04.025 | Sodium-dependent dopamine transporter | 1 |
Data from ChEMBL 36 via Core Engine