Assay Detail
Binding
CHEMBL930496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DAT
47
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.48 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409715 | — | — | 1 | 6.19 |
| CHEMBL255303 | — | — | 1 | 5.89 |
| CHEMBL404729 | — | — | 1 | 5.54 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 5.51 |
| CHEMBL99946 | LEVOMILNACIPRAN | 4.0 | 1 | 5.50 |
| CHEMBL411033 | — | — | 1 | 5.44 |
| CHEMBL264430 | — | — | 1 | 5.44 |
| CHEMBL260440 | — | — | 1 | 5.41 |
| CHEMBL408384 | — | — | 1 | 5.37 |
| CHEMBL257550 | — | — | 1 | 5.37 |
| CHEMBL260336 | — | — | 1 | 5.35 |
| CHEMBL411655 | — | — | 1 | 5.29 |
| CHEMBL259209 | MILNACIPRAN | 4.0 | 2 | 5.21 |
| CHEMBL256557 | — | — | 1 | 5.20 |
| CHEMBL402441 | — | — | 1 | - |
| CHEMBL405462 | — | — | 1 | - |
| CHEMBL427904 | — | — | 1 | - |
| CHEMBL260439 | — | — | 1 | - |
| CHEMBL260335 | — | — | 1 | - |
| CHEMBL410062 | — | — | 1 | - |
| CHEMBL257551 | — | — | 1 | - |
| CHEMBL257549 | — | — | 1 | - |
| CHEMBL404145 | — | — | 1 | - |
| CHEMBL258450 | — | — | 1 | - |
| CHEMBL408940 | — | — | 1 | - |
| CHEMBL260988 | — | — | 1 | - |
| CHEMBL404013 | — | — | 1 | - |
| CHEMBL403949 | — | — | 1 | - |
| CHEMBL403469 | — | — | 1 | - |
| CHEMBL258180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409715 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL255303 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL404729 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL99946 | LEVOMILNACIPRAN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL264430 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL411033 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL260440 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL257550 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL408384 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL260336 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL411655 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL259209 | MILNACIPRAN | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL256557 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL258451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL257335 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL404730 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL257336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260131 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL408016 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL405613 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL411677 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL264678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410015 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260863 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL259694 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL406789 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL405728 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410055 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL404145 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL408940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260335 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL404013 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL403469 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL258180 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL403949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL258450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260439 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL402441 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260988 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL259209 | MILNACIPRAN | IC50 | > | 10000.0 | nM | - |
| CHEMBL257549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL257551 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410062 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL427904 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL405462 | — | IC50 | > | 10000.0 | nM | - |