Assay Detail
Functional
CHEMBL930622
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Inhibition of LPS-stimulated TNFalpha release in human whole blood
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.87 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401263 | — | — | 1 | 7.62 |
| CHEMBL256621 | — | — | 1 | 7.48 |
| CHEMBL438528 | — | — | 1 | 7.34 |
| CHEMBL429589 | — | — | 1 | 7.30 |
| CHEMBL401979 | — | — | 1 | 7.18 |
| CHEMBL270819 | — | — | 1 | 7.17 |
| CHEMBL272341 | — | — | 1 | 7.12 |
| CHEMBL235997 | — | — | 1 | 7.12 |
| CHEMBL256681 | — | — | 1 | 7.10 |
| CHEMBL270800 | — | — | 1 | 7.01 |
| CHEMBL271235 | — | — | 1 | 6.96 |
| CHEMBL257532 | — | — | 1 | 6.92 |
| CHEMBL403401 | — | — | 1 | 6.78 |
| CHEMBL271234 | — | — | 1 | 6.72 |
| CHEMBL257531 | — | — | 1 | 6.71 |
| CHEMBL270606 | — | — | 1 | 6.71 |
| CHEMBL404162 | — | — | 1 | 6.68 |
| CHEMBL256805 | — | — | 1 | 6.65 |
| CHEMBL441901 | — | — | 1 | 6.59 |
| CHEMBL401824 | — | — | 1 | 6.52 |
| CHEMBL439066 | — | — | 1 | 6.50 |
| CHEMBL256598 | — | — | 1 | 6.39 |
| CHEMBL402746 | — | — | 1 | 6.32 |
| CHEMBL256245 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401263 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL256621 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL438528 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL429589 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL401979 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL270819 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL272341 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL235997 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL256681 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL270800 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL271235 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL257532 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL403401 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL271234 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL257531 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL270606 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL404162 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL256805 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL441901 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL401824 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL439066 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL256598 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL402746 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL256245 | — | IC50 | = | 880.0 | nM | 6.06 |