Assay Detail
Binding
CHEMBL930623
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Inhibition of pig TACE
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3332) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.84 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271235 | — | — | 1 | 9.85 |
| CHEMBL403401 | — | — | 1 | 9.40 |
| CHEMBL270800 | — | — | 1 | 9.03 |
| CHEMBL256805 | — | — | 1 | 9.00 |
| CHEMBL401263 | — | — | 1 | 9.00 |
| CHEMBL271234 | — | — | 1 | 9.00 |
| CHEMBL256621 | — | — | 1 | 9.00 |
| CHEMBL402746 | — | — | 1 | 9.00 |
| CHEMBL441901 | — | — | 1 | 8.96 |
| CHEMBL401979 | — | — | 1 | 8.89 |
| CHEMBL404162 | — | — | 1 | 8.82 |
| CHEMBL256598 | — | — | 1 | 8.82 |
| CHEMBL429589 | — | — | 1 | 8.80 |
| CHEMBL256245 | — | — | 1 | 8.80 |
| CHEMBL256681 | — | — | 1 | 8.80 |
| CHEMBL272341 | — | — | 1 | 8.74 |
| CHEMBL439066 | — | — | 1 | 8.70 |
| CHEMBL270819 | — | — | 1 | 8.68 |
| CHEMBL438528 | — | — | 1 | 8.64 |
| CHEMBL270606 | — | — | 1 | 8.57 |
| CHEMBL257532 | — | — | 1 | 8.34 |
| CHEMBL235997 | — | — | 1 | 8.20 |
| CHEMBL401824 | — | — | 1 | 8.20 |
| CHEMBL257531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271235 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL403401 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL270800 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL256805 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL401263 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL271234 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL256621 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL402746 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL441901 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL401979 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL404162 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL256598 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL429589 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL256245 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL256681 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL272341 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL439066 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL270819 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL438528 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL270606 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL257532 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL235997 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL401824 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL257531 | — | IC50 | < | 1.0 | nM | - |