Assay Detail
Functional
CHEMBL930742
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Cytostatic activity against human HL60 cells ATCC CCL 240 assessed as cell viability by XTT test
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.76 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403961 | — | — | 1 | 6.51 |
| CHEMBL256484 | — | — | 1 | 6.36 |
| CHEMBL272563 | — | — | 1 | 6.24 |
| CHEMBL271483 | — | — | 1 | 6.21 |
| CHEMBL271484 | — | — | 1 | 6.09 |
| CHEMBL403830 | — | — | 1 | 6.08 |
| CHEMBL402160 | — | — | 1 | 4.86 |
| CHEMBL271031 | — | — | 1 | 4.76 |
| CHEMBL403816 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403961 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL256484 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL272563 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL271483 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL271484 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL403830 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL402160 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL271031 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL403816 | — | IC50 | = | 17700.0 | nM | 4.75 |