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Assay Detail

CHEMBL930744

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCV 1b Con1 replicon in Huh7 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis C virus subtype 1b
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides.
Kuchar M, Hocek M, Pohl R, Votruba I, Shih IH, Mabery E, Mackman R.
Bioorg Med Chem (2008) 16 : 1400 -1424
PubMed 17997319 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 5.17 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73809 1 6.64
CHEMBL272563 1 6.47
CHEMBL403830 1 6.00
CHEMBL256484 1 6.00
CHEMBL271483 1 5.40
CHEMBL271484 1 5.40
CHEMBL403961 1 5.30
CHEMBL402160 1 5.25
CHEMBL257655 1 5.22
CHEMBL271031 1 5.17
CHEMBL271305 1 5.16
CHEMBL403816 1 4.96
CHEMBL403375 1 4.60
CHEMBL270585 1 4.43
CHEMBL401671 1 4.40
CHEMBL271306 1 4.28
CHEMBL272760 1 4.27
CHEMBL410078 1 4.07
CHEMBL271304 1 -
CHEMBL257642 1 -
CHEMBL272759 1 -
CHEMBL443229 1 -
CHEMBL404196 1 -
CHEMBL403973 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73809 EC50 = 230.0 nM 6.64
CHEMBL272563 EC50 = 340.0 nM 6.47
CHEMBL403830 EC50 = 1000.0 nM 6.00
CHEMBL256484 EC50 = 1000.0 nM 6.00
CHEMBL271483 EC50 = 4000.0 nM 5.40
CHEMBL271484 EC50 = 4000.0 nM 5.40
CHEMBL403961 EC50 = 5000.0 nM 5.30
CHEMBL402160 EC50 = 5600.0 nM 5.25
CHEMBL257655 EC50 = 6000.0 nM 5.22
CHEMBL271031 EC50 = 6700.0 nM 5.17
CHEMBL271305 EC50 = 7000.0 nM 5.16
CHEMBL403816 EC50 = 11000.0 nM 4.96
CHEMBL403375 EC50 = 25000.0 nM 4.60
CHEMBL270585 EC50 = 37000.0 nM 4.43
CHEMBL401671 EC50 = 40000.0 nM 4.40
CHEMBL271306 EC50 = 53000.0 nM 4.28
CHEMBL272760 EC50 = 54000.0 nM 4.27
CHEMBL410078 EC50 = 85000.0 nM 4.07
CHEMBL271304 EC50 > 100000.0 nM -
CHEMBL257642 EC50 = 116000.0 nM -
CHEMBL272759 EC50 > 100000.0 nM -
CHEMBL443229 EC50 > 100000.0 nM -
CHEMBL404196 EC50 > 100000.0 nM -
CHEMBL403973 EC50 > 100000.0 nM -