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Assay Detail

CHEMBL930964

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Azaterphenyl diamidines as antileishmanial agents.
Hu L, Arafa RK, Ismail MA, Wenzler T, Brun R, Munde M, Wilson WD, Nzimiro S, Samyesudhas S, Werbovetz KA, Boykin DW.
Bioorg Med Chem Lett (2008) 18 : 247 -251
PubMed 18006310 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.84 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL258320 1 5.92
CHEMBL257422 1 5.66
CHEMBL256247 1 5.55
CHEMBL402847 1 5.33
CHEMBL271656 1 5.28
CHEMBL256797 1 5.19
CHEMBL424711 1 5.19
CHEMBL255539 1 4.70
CHEMBL215692 1 4.66
CHEMBL213259 1 4.58
CHEMBL258319 1 4.57
CHEMBL256795 1 4.55
CHEMBL272090 1 4.51
CHEMBL211920 1 4.39
CHEMBL403091 1 4.37
CHEMBL255758 1 4.33
CHEMBL215484 1 4.30
CHEMBL273018 1 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL258320 IC50 = 1200.0 nM 5.92
CHEMBL257422 IC50 = 2200.0 nM 5.66
CHEMBL256247 IC50 = 2800.0 nM 5.55
CHEMBL402847 IC50 = 4700.0 nM 5.33
CHEMBL271656 IC50 = 5300.0 nM 5.28
CHEMBL256797 IC50 = 6400.0 nM 5.19
CHEMBL424711 IC50 = 6400.0 nM 5.19
CHEMBL255539 IC50 = 20000.0 nM 4.70
CHEMBL215692 IC50 = 22000.0 nM 4.66
CHEMBL213259 IC50 = 26000.0 nM 4.58
CHEMBL258319 IC50 = 27000.0 nM 4.57
CHEMBL256795 IC50 = 28000.0 nM 4.55
CHEMBL272090 IC50 = 31000.0 nM 4.51
CHEMBL211920 IC50 = 41000.0 nM 4.39
CHEMBL403091 IC50 = 43000.0 nM 4.37
CHEMBL255758 IC50 = 47000.0 nM 4.33
CHEMBL215484 IC50 = 50000.0 nM 4.30
CHEMBL273018 IC50 = 93000.0 nM 4.03