Assay Detail
Functional
CHEMBL930968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at LPA2 expressed in RH7777 cells with Gi4-protein and aequorin by calcium mobilization assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | RH7777 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.33 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256470 | — | — | 1 | 7.77 |
| CHEMBL270865 | — | — | 1 | 7.46 |
| CHEMBL401756 | — | — | 1 | 6.77 |
| CHEMBL404452 | — | — | 1 | 6.58 |
| CHEMBL427893 | — | — | 1 | 6.51 |
| CHEMBL401747 | — | — | 1 | 6.14 |
| CHEMBL429681 | — | — | 1 | 6.14 |
| CHEMBL270877 | — | — | 1 | 5.89 |
| CHEMBL401543 | — | — | 1 | 5.73 |
| CHEMBL270878 | — | — | 1 | 5.50 |
| CHEMBL270237 | — | — | 1 | 5.18 |
| CHEMBL256478 | — | — | 1 | - |
| CHEMBL272352 | — | — | 1 | - |
| CHEMBL406676 | — | — | 1 | - |
| CHEMBL257899 | — | — | 1 | - |
| CHEMBL272087 | — | — | 1 | - |
| CHEMBL404575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256470 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL270865 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL401756 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL404452 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL427893 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL401747 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL429681 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL270877 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL401543 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL270878 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL270237 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL256478 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL272352 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL406676 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL257899 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL272087 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL404575 | — | IC50 | > | 50000.0 | nM | - |