Assay Detail
Functional
CHEMBL931092
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Antileukemic activity in human HL60 cells assessed as nitric oxide release
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.37 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455983 | — | — | 1 | 6.70 |
| CHEMBL272318 | — | — | 1 | 5.77 |
| CHEMBL258266 | — | — | 1 | 5.70 |
| CHEMBL211413 | — | — | 1 | 5.64 |
| CHEMBL403072 | — | — | 1 | 5.60 |
| CHEMBL255622 | — | — | 1 | 5.50 |
| CHEMBL271666 | — | — | 1 | 5.35 |
| CHEMBL258118 | — | — | 1 | 5.30 |
| CHEMBL404314 | — | — | 1 | 5.22 |
| CHEMBL255161 | — | — | 1 | 5.18 |
| CHEMBL213693 | — | — | 1 | 5.17 |
| CHEMBL258116 | — | — | 1 | 5.14 |
| CHEMBL403114 | — | — | 1 | 5.13 |
| CHEMBL271682 | — | — | 1 | 5.13 |
| CHEMBL273201 | — | — | 1 | 5.08 |
| CHEMBL271664 | — | — | 1 | 5.06 |
| CHEMBL404098 | — | — | 1 | 5.04 |
| CHEMBL271683 | — | — | 1 | 5.01 |
| CHEMBL429607 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455983 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL272318 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL258266 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL211413 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL403072 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL255622 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL271666 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL258118 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL404314 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL255161 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL213693 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL258116 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL403114 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL271682 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL273201 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL271664 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL404098 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL271683 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL429607 | — | IC50 | > | 50000.0 | nM | - |