Assay Detail
Functional
CHEMBL931203
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Effect on Wnt/beta-casein reporter pathway in HEK293 cells expressing super(8X)TOPFlash reporter assessed as luciferase activity in presence of Wnt-3a
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small-molecule synergist of the Wnt/beta-catenin signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.91 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404773 | — | — | 1 | 6.40 |
| CHEMBL259181 | — | — | 1 | 6.30 |
| CHEMBL265685 | — | — | 1 | 6.22 |
| CHEMBL260162 | — | — | 1 | 5.82 |
| CHEMBL261879 | — | — | 1 | 5.77 |
| CHEMBL406603 | — | — | 1 | 5.51 |
| CHEMBL405112 | — | — | 1 | 5.34 |
| CHEMBL259182 | — | — | 1 | - |
| CHEMBL428131 | — | — | 1 | - |
| CHEMBL261353 | — | — | 1 | - |
| CHEMBL407988 | — | — | 1 | - |
| CHEMBL263110 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404773 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL259181 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL265685 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL260162 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL261879 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL406603 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL405112 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL259182 | — | EC50 | > | 7100.0 | nM | - |
| CHEMBL428131 | — | EC50 | > | 7100.0 | nM | - |
| CHEMBL261353 | — | EC50 | > | 7100.0 | nM | - |
| CHEMBL407988 | — | EC50 | > | 7100.0 | nM | - |
| CHEMBL263110 | — | EC50 | > | 7100.0 | nM | - |