Assay Detail
Functional
CHEMBL931259
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Antagonist activity against TP receptor by FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.08 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257997 | — | — | 1 | 7.50 |
| CHEMBL257134 | — | — | 1 | 7.30 |
| CHEMBL255675 | — | — | 1 | 7.10 |
| CHEMBL403407 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257997 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL257134 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL255675 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL403407 | — | Ki | = | 398.11 | nM | 6.40 |