Assay Detail
Binding
CHEMBL931445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M3 receptor expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.99 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381623 | — | — | 1 | 9.90 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 9.70 |
| CHEMBL428962 | — | — | 1 | 9.70 |
| CHEMBL1908368 | — | — | 1 | 9.50 |
| CHEMBL264676 | — | — | 1 | 9.50 |
| CHEMBL409151 | — | — | 1 | 9.50 |
| CHEMBL264414 | — | — | 1 | 8.70 |
| CHEMBL258959 | — | — | 1 | 8.60 |
| CHEMBL260228 | — | — | 1 | 8.60 |
| CHEMBL371734 | — | — | 1 | 8.40 |
| CHEMBL411514 | — | — | 1 | 8.00 |
| CHEMBL410061 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381623 | — | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL428962 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL1908368 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL264676 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL409151 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL264414 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL258959 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL260228 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL371734 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL411514 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL410061 | — | Ki | = | 15.85 | nM | 7.80 |