Assay Detail
Binding
CHEMBL931622
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Inhibition of HDAC3 in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.32 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.44 |
| CHEMBL430060 | APICIDIN | — | 1 | 8.01 |
| CHEMBL112446 | — | — | 1 | 8.00 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.34 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.24 |
| CHEMBL115011 | — | — | 1 | 6.92 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.40 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL430060 | APICIDIN | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL112446 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL115011 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 610.0 | nM | 6.21 |