Assay Detail
Binding
CHEMBL931623
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Inhibition of HDAC4 H976Y mutant expressed in Escherichia coli
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.88 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.36 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.62 |
| CHEMBL115011 | — | — | 1 | 6.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.27 |
| CHEMBL430060 | APICIDIN | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL115011 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL430060 | APICIDIN | IC50 | = | 3600.0 | nM | 5.44 |