Assay Detail
Binding
CHEMBL931725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Streptococcus pneumoniae MTAN
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptococcus pneumoniae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (CHEMBL1075023) ↗| Type | SINGLE PROTEIN |
| Organism | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Publication
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.17 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405346 | — | — | 1 | 7.62 |
| CHEMBL405371 | — | — | 1 | 7.08 |
| CHEMBL407216 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405346 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL405371 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL407216 | — | Ki | = | 150.0 | nM | 6.82 |