Assay Detail
Binding
CHEMBL931815
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Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.41 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.42 |
| CHEMBL271681 | — | — | 1 | 6.40 |
| CHEMBL420843 | — | — | 1 | 6.22 |
| CHEMBL252036 | GS-9148 | -1.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL271681 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL420843 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL252036 | GS-9148 | IC50 | = | 1900.0 | nM | 5.72 |