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Assay Detail

CHEMBL931829

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Functional
Antitumor activity against human A549 cells after 4 hrs by MTT assay
ChEMBL ↗
98
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

New homocamptothecins: synthesis, antitumor activity, and molecular modeling.
Miao Z, Sheng C, Zhang W, Ji H, Zhang J, Shao L, You L, Zhang M, Yao J, Che X.
Bioorg Med Chem (2008) 16 : 1493 -1510
PubMed 18207748 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 98 6.79 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404149 — — 2 9.22
CHEMBL271465 — — 2 9.10
CHEMBL270425 — — 2 9.05
CHEMBL411872 — — 2 9.05
CHEMBL401635 — — 2 8.70
CHEMBL255187 — — 2 8.70
CHEMBL272726 — — 2 8.70
CHEMBL271466 — — 2 8.52
CHEMBL84 TOPOTECAN 4.0 1 8.30
CHEMBL271875 — — 2 8.15
CHEMBL255217 — — 2 7.89
CHEMBL404573 — — 2 7.77
CHEMBL404838 — — 2 7.58
CHEMBL401755 — — 2 7.42
CHEMBL255188 — — 2 7.03
CHEMBL429573 — — 2 6.65
CHEMBL403643 — — 2 6.54
CHEMBL411639 — — 2 6.50
CHEMBL270449 — — 2 6.42
CHEMBL272056 — — 2 6.27
CHEMBL269993 — — 2 6.14
CHEMBL404302 — — 2 6.08
CHEMBL403974 — — 2 5.95
CHEMBL273133 — — 2 5.70
CHEMBL272982 — — 2 5.68
CHEMBL271891 — — 2 5.67
CHEMBL270211 — — 2 5.62
CHEMBL255365 — — 2 5.54
CHEMBL255366 — — 2 5.46
CHEMBL255563 — — 2 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404149 — IC50 = 0.6 nM 9.22
CHEMBL271465 — IC50 = 0.8 nM 9.10
CHEMBL411872 — IC50 = 0.9 nM 9.05
CHEMBL270425 — IC50 = 0.9 nM 9.05
CHEMBL401635 — IC50 = 2.0 nM 8.70
CHEMBL272726 — IC50 = 2.0 nM 8.70
CHEMBL255187 — IC50 = 2.0 nM 8.70
CHEMBL271466 — IC50 = 3.0 nM 8.52
CHEMBL84 TOPOTECAN IC50 = 5.0 nM 8.30
CHEMBL271875 — IC50 = 7.0 nM 8.15
CHEMBL255217 — IC50 = 13.0 nM 7.89
CHEMBL404573 — IC50 = 17.0 nM 7.77
CHEMBL404838 — IC50 = 26.0 nM 7.58
CHEMBL401755 — IC50 = 38.0 nM 7.42
CHEMBL255188 — IC50 = 93.0 nM 7.03
CHEMBL429573 — IC50 = 226.0 nM 6.65
CHEMBL403643 — IC50 = 290.0 nM 6.54
CHEMBL411639 — IC50 = 313.0 nM 6.50
CHEMBL270449 — IC50 = 381.0 nM 6.42
CHEMBL272056 — IC50 = 538.0 nM 6.27
CHEMBL269993 — IC50 = 729.0 nM 6.14
CHEMBL404302 — IC50 = 828.0 nM 6.08
CHEMBL403974 — IC50 = 1122.0 nM 5.95
CHEMBL273133 — IC50 = 2017.0 nM 5.70
CHEMBL272982 — IC50 = 2072.0 nM 5.68
CHEMBL271891 — IC50 = 2114.0 nM 5.67
CHEMBL270211 — IC50 = 2391.0 nM 5.62
CHEMBL255365 — IC50 = 2850.0 nM 5.54
CHEMBL255366 — IC50 = 3490.0 nM 5.46
CHEMBL255563 — IC50 = 5015.0 nM 5.30
CHEMBL255425 — IC50 = 5822.0 nM 5.24
CHEMBL481 IRINOTECAN IC50 = 6528.0 nM 5.18
CHEMBL404403 — IC50 = 7316.0 nM 5.14
CHEMBL404617 — IC50 = 13926.0 nM 4.86
CHEMBL271665 — IC50 = 18282.0 nM 4.74
CHEMBL401634 — IC50 = 19608.0 nM 4.71
CHEMBL404712 — IC50 = 5000345349769.78 nM -
CHEMBL411872 — IC50 = 1111219873768.73 nM -
CHEMBL427894 — IC50 = 5000345349769.78 nM -
CHEMBL401635 — IC50 = 500034534976.98 nM -
CHEMBL407463 — IC50 = 5000345349769.78 nM -
CHEMBL403974 — IC50 = 891250938.13 nM -
CHEMBL273133 — IC50 = 474569693.19 nM -
CHEMBL270211 — IC50 = 418215379.91 nM -
CHEMBL411639 — IC50 = 3195214364.81 nM -
CHEMBL403643 — IC50 = 3448259965.53 nM -
CHEMBL270449 — IC50 = 2624822861.61 nM -
CHEMBL271875 — IC50 = 142856498139.46 nM -
CHEMBL401634 — IC50 = 52444506.13 nM -
CHEMBL271665 — IC50 = 54701596.29 nM -