Assay Detail
Functional
CHEMBL931968
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Antagonist activity at LPA3 expressed in RH7777 cells with Gi4-protein and aequorin by calcium mobilization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | RH7777 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.16 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272087 | — | — | 1 | 7.40 |
| CHEMBL404575 | — | — | 1 | 4.92 |
| CHEMBL404452 | — | — | 1 | - |
| CHEMBL256470 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272087 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL404575 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL404452 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL256470 | — | IC50 | > | 50000.0 | nM | - |