Assay Detail
Binding
CHEMBL932016
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Inhibition of AChE by Ellman's assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.59 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407320 | — | — | 1 | 8.25 |
| CHEMBL261384 | — | — | 1 | 8.20 |
| CHEMBL270491 | — | — | 1 | 8.19 |
| CHEMBL272229 | — | — | 1 | 8.00 |
| CHEMBL277984 | — | — | 1 | 7.96 |
| CHEMBL260308 | — | — | 1 | 7.74 |
| CHEMBL271385 | — | — | 1 | 7.67 |
| CHEMBL273078 | — | — | 1 | 7.65 |
| CHEMBL269865 | — | — | 1 | 7.55 |
| CHEMBL273051 | — | — | 1 | 7.45 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.35 |
| CHEMBL272230 | — | — | 1 | 7.34 |
| CHEMBL260964 | — | — | 1 | 7.29 |
| CHEMBL270349 | — | — | 1 | 7.16 |
| CHEMBL269863 | — | — | 1 | 7.03 |
| CHEMBL271746 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407320 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL261384 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL270491 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL272229 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL277984 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL260308 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL271385 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL273078 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL269865 | — | IC50 | = | 28.2 | nM | 7.55 |
| CHEMBL273051 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL95 | TACRINE | IC50 | = | 45.1 | nM | 7.35 |
| CHEMBL272230 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL260964 | — | IC50 | = | 50.7 | nM | 7.29 |
| CHEMBL270349 | — | IC50 | = | 69.5 | nM | 7.16 |
| CHEMBL269863 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL271746 | — | IC50 | = | 226.0 | nM | 6.65 |