Assay Detail
Binding
CHEMBL932017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BuChE by Ellman's assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.91 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.29 |
| CHEMBL272229 | — | — | 1 | 8.28 |
| CHEMBL270349 | — | — | 1 | 8.26 |
| CHEMBL270491 | — | — | 1 | 8.26 |
| CHEMBL271746 | — | — | 1 | 8.14 |
| CHEMBL407320 | — | — | 1 | 8.00 |
| CHEMBL260308 | — | — | 1 | 7.97 |
| CHEMBL273078 | — | — | 1 | 7.92 |
| CHEMBL269865 | — | — | 1 | 7.87 |
| CHEMBL277984 | — | — | 1 | 7.86 |
| CHEMBL273051 | — | — | 1 | 7.82 |
| CHEMBL272230 | — | — | 1 | 7.82 |
| CHEMBL261384 | — | — | 1 | 7.66 |
| CHEMBL269863 | — | — | 1 | 7.55 |
| CHEMBL271385 | — | — | 1 | 7.44 |
| CHEMBL260964 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL272229 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL270349 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL270491 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL271746 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL407320 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL260308 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL273078 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL269865 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL277984 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL273051 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL272230 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL261384 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL269863 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL271385 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL260964 | — | IC50 | = | 41.0 | nM | 7.39 |