Assay Detail
Binding
CHEMBL932205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M4 receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of a fluorescent muscarinic antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.66 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.51 |
| CHEMBL271108 | — | — | 1 | 8.20 |
| CHEMBL257431 | — | — | 1 | 6.99 |
| CHEMBL257643 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1382 | TOLTERODINE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL271108 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL257431 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL257643 | — | Ki | = | 121.0 | nM | 6.92 |