Assay Detail
Binding
CHEMBL932207
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Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.84 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34546 | — | — | 1 | 8.07 |
| CHEMBL34016 | — | — | 1 | 8.05 |
| CHEMBL285962 | — | — | 1 | 8.05 |
| CHEMBL34526 | — | — | 1 | 8.03 |
| CHEMBL286862 | — | — | 1 | 8.02 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL284694 | — | — | 1 | 6.41 |
| CHEMBL285436 | — | — | 1 | 6.36 |
| CHEMBL432083 | — | — | 1 | 6.31 |
| CHEMBL286449 | — | — | 1 | 6.24 |
| CHEMBL287145 | — | — | 1 | 6.24 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 4.73 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34546 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL34016 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL285962 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL34526 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL286862 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL284694 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL285436 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL432083 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL286449 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL287145 | — | Ki | = | 578.0 | nM | 6.24 |
| CHEMBL310671 | SACCHARIN | Ki | = | 18540.0 | nM | 4.73 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 25000.0 | nM | 4.60 |