Assay Detail
Binding
CHEMBL932301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghosts
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 5.01 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL772 | RESERPINE | 4.0 | 1 | 9.00 |
| CHEMBL117785 | TETRABENAZINE | 4.0 | 1 | 8.40 |
| CHEMBL272202 | — | — | 1 | 6.40 |
| CHEMBL404601 | — | — | 1 | 6.30 |
| CHEMBL406761 | — | — | 1 | 5.85 |
| CHEMBL271568 | — | — | 1 | 5.62 |
| CHEMBL272201 | — | — | 1 | 5.55 |
| CHEMBL270469 | — | — | 1 | 5.35 |
| CHEMBL270771 | — | — | 1 | 5.12 |
| CHEMBL411716 | — | — | 1 | 5.00 |
| CHEMBL260949 | — | — | 1 | 4.87 |
| CHEMBL408246 | — | — | 1 | 4.79 |
| CHEMBL271567 | — | — | 1 | 4.61 |
| CHEMBL552965 | — | — | 1 | 4.59 |
| CHEMBL537474 | — | — | 1 | 4.56 |
| CHEMBL271566 | — | — | 1 | 4.47 |
| CHEMBL270770 | — | — | 1 | 4.44 |
| CHEMBL260951 | — | — | 1 | 4.42 |
| CHEMBL536788 | — | — | 1 | 4.42 |
| CHEMBL555612 | — | — | 1 | 4.33 |
| CHEMBL539867 | — | — | 1 | 4.30 |
| CHEMBL273074 | — | — | 1 | 4.29 |
| CHEMBL261603 | — | — | 1 | 4.29 |
| CHEMBL260950 | — | — | 1 | 4.28 |
| CHEMBL260733 | — | — | 1 | 4.28 |
| CHEMBL168464 | — | — | 1 | 4.28 |
| CHEMBL271522 | — | — | 1 | 4.19 |
| CHEMBL271569 | — | — | 1 | 4.09 |
| CHEMBL271379 | — | — | 1 | 4.04 |
| CHEMBL271570 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL772 | RESERPINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL117785 | TETRABENAZINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL272202 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL404601 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL406761 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL271568 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL272201 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL270469 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL270771 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL411716 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL260949 | — | Ki | = | 13400.0 | nM | 4.87 |
| CHEMBL408246 | — | Ki | = | 16400.0 | nM | 4.79 |
| CHEMBL271567 | — | Ki | = | 24600.0 | nM | 4.61 |
| CHEMBL552965 | — | Ki | = | 25800.0 | nM | 4.59 |
| CHEMBL537474 | — | Ki | = | 27700.0 | nM | 4.56 |
| CHEMBL271566 | — | Ki | = | 33800.0 | nM | 4.47 |
| CHEMBL270770 | — | Ki | = | 36600.0 | nM | 4.44 |
| CHEMBL260951 | — | Ki | = | 38400.0 | nM | 4.42 |
| CHEMBL536788 | — | Ki | = | 38400.0 | nM | 4.42 |
| CHEMBL555612 | — | Ki | = | 46300.0 | nM | 4.33 |
| CHEMBL539867 | — | Ki | = | 49700.0 | nM | 4.30 |
| CHEMBL273074 | — | Ki | = | 51300.0 | nM | 4.29 |
| CHEMBL261603 | — | Ki | = | 51800.0 | nM | 4.29 |
| CHEMBL260950 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL260733 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL168464 | — | Ki | = | 52500.0 | nM | 4.28 |
| CHEMBL271522 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL271569 | — | Ki | = | 82000.0 | nM | 4.09 |
| CHEMBL271379 | — | Ki | = | 92000.0 | nM | 4.04 |
| CHEMBL271570 | — | Ki | = | 95000.0 | nM | 4.02 |
| CHEMBL261822 | — | Ki | = | 338000.0 | nM | - |
| CHEMBL537675 | — | Ki | = | 193000.0 | nM | - |
| CHEMBL406268 | — | Ki | = | 106000.0 | nM | - |
| CHEMBL537234 | — | Ki | = | 134000.0 | nM | - |