Assay Detail
Functional
CHEMBL932402
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Activity at human CB1R expressed in HEK293 cells assessed as intracellular cAMP level
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 7.94 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260625 | — | — | 1 | 8.92 |
| CHEMBL410339 | — | — | 1 | 8.70 |
| CHEMBL259654 | — | — | 1 | 8.70 |
| CHEMBL408427 | — | — | 1 | 8.70 |
| CHEMBL262857 | — | — | 1 | 8.52 |
| CHEMBL409471 | — | — | 1 | 8.52 |
| CHEMBL409217 | — | — | 1 | 8.40 |
| CHEMBL263391 | — | — | 1 | 8.30 |
| CHEMBL258753 | — | — | 1 | 8.30 |
| CHEMBL258539 | — | — | 1 | 8.10 |
| CHEMBL259656 | — | — | 1 | 7.96 |
| CHEMBL410247 | — | — | 1 | 7.96 |
| CHEMBL410248 | — | — | 1 | 7.58 |
| CHEMBL409472 | — | — | 1 | 7.14 |
| CHEMBL260810 | — | — | 1 | 6.81 |
| CHEMBL409441 | — | — | 1 | 6.33 |
| CHEMBL260284 | — | — | 1 | 6.11 |
| CHEMBL428257 | — | — | 1 | - |
| CHEMBL405888 | — | — | 1 | - |
| CHEMBL263390 | — | — | 1 | - |
| CHEMBL263128 | — | — | 1 | - |
| CHEMBL263129 | — | — | 1 | - |
| CHEMBL259699 | — | — | 1 | - |
| CHEMBL262858 | — | — | 1 | - |
| CHEMBL411054 | — | — | 1 | - |
| CHEMBL259425 | — | — | 1 | - |
| CHEMBL259339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260625 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL410339 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL259654 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL408427 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL262857 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL409471 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL409217 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL263391 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL258753 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL258539 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL259656 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL410247 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL410248 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL409472 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL260810 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL409441 | — | EC50 | = | 466.0 | nM | 6.33 |
| CHEMBL260284 | — | EC50 | = | 784.0 | nM | 6.11 |
| CHEMBL428257 | — | EC50 | - | — | - | |
| CHEMBL405888 | — | EC50 | - | — | - | |
| CHEMBL263390 | — | EC50 | - | — | - | |
| CHEMBL263128 | — | EC50 | - | — | - | |
| CHEMBL263129 | — | EC50 | - | — | - | |
| CHEMBL259699 | — | EC50 | - | — | - | |
| CHEMBL262858 | — | EC50 | - | — | - | |
| CHEMBL411054 | — | EC50 | - | — | - | |
| CHEMBL259425 | — | EC50 | - | — | - | |
| CHEMBL259339 | — | EC50 | - | — | - |