Assay Detail
Functional
CHEMBL932441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Trypanosoma brucei rhodesiense STIB 900 after 3 days
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Novel bisbenzimidazoles with antileishmanial effectiveness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.69 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.30 |
| CHEMBL428119 | — | — | 1 | 6.07 |
| CHEMBL428612 | — | — | 1 | - |
| CHEMBL258555 | — | — | 1 | - |
| CHEMBL258556 | — | — | 1 | - |
| CHEMBL403651 | — | — | 1 | - |
| CHEMBL442471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL428119 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL428612 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL258555 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL258556 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL403651 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL442471 | — | IC50 | > | 60000.0 | nM | - |