Assay Detail
Functional
CHEMBL932501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK inhibitor 2 by trypan blue exclusion method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BJ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.05 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401989 | ERASTIN | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401989 | ERASTIN | IC50 | = | 900.0 | nM | 6.05 |