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Assay Detail

CHEMBL932549

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Functional
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in presence of iron deficient GAST-D medium
ChEMBL ↗
65
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Intermediate

Target

Mycobacterium tuberculosis (CHEMBL360) ↗
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.
Stirrett KL, Ferreras JA, Jayaprakash V, Sinha BN, Ren T, Quadri LE.
Bioorg Med Chem Lett (2008) 18 : 2662 -2668
PubMed 18394884 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
MIC90 33 - -
IC50 32 4.49 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL402834 — — 2 5.52
CHEMBL256541 — — 2 5.10
CHEMBL258166 — — 2 4.62
CHEMBL256080 — — 2 4.57
CHEMBL404731 — — 2 4.55
CHEMBL256079 — — 2 4.55
CHEMBL256351 — — 2 4.54
CHEMBL255234 — — 2 4.54
CHEMBL258440 — — 2 4.29
CHEMBL404040 — — 2 4.20
CHEMBL257574 — — 2 4.14
CHEMBL257397 — — 2 4.10
CHEMBL258378 — — 2 4.08
CHEMBL255241 — — 2 4.08
CHEMBL403142 — — 2 -
CHEMBL255008 — — 2 -
CHEMBL255435 — — 2 -
CHEMBL427902 — — 2 -
CHEMBL444374 — — 2 -
CHEMBL402821 — — 2 -
CHEMBL258034 — — 2 -
CHEMBL255894 — — 2 -
CHEMBL403164 — — 2 -
CHEMBL403496 — — 2 -
CHEMBL257780 — — 2 -
CHEMBL256545 — — 2 -
CHEMBL256309 — — 2 -
CHEMBL374478 RIFAMPIN 4.0 1 -
CHEMBL256128 — — 2 -
CHEMBL257608 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL402834 — IC50 = 3000.0 nM 5.52
CHEMBL256541 — IC50 = 8000.0 nM 5.10
CHEMBL258166 — IC50 = 24000.0 nM 4.62
CHEMBL256080 — IC50 = 27000.0 nM 4.57
CHEMBL404731 — IC50 = 28000.0 nM 4.55
CHEMBL256079 — IC50 = 28000.0 nM 4.55
CHEMBL256351 — IC50 = 29000.0 nM 4.54
CHEMBL255234 — IC50 = 29000.0 nM 4.54
CHEMBL258440 — IC50 = 51000.0 nM 4.29
CHEMBL404040 — IC50 = 63000.0 nM 4.20
CHEMBL257574 — IC50 = 73000.0 nM 4.14
CHEMBL257397 — IC50 = 80000.0 nM 4.10
CHEMBL258378 — IC50 = 83000.0 nM 4.08
CHEMBL255241 — IC50 = 84000.0 nM 4.08
CHEMBL256351 — MIC90 = 83000.0 nM -
CHEMBL427902 — MIC90 >= 500000.0 nM -
CHEMBL256545 — IC50 >= 500000.0 nM -
CHEMBL444374 — IC50 >= 500000.0 nM -
CHEMBL256545 — MIC90 >= 500000.0 nM -
CHEMBL402966 — IC50 >= 500000.0 nM -
CHEMBL402966 — MIC90 >= 500000.0 nM -
CHEMBL404041 — IC50 >= 500000.0 nM -
CHEMBL404041 — MIC90 >= 500000.0 nM -
CHEMBL402040 — IC50 >= 500000.0 nM -
CHEMBL402040 — MIC90 >= 500000.0 nM -
CHEMBL403142 — IC50 >= 500000.0 nM -
CHEMBL403142 — MIC90 >= 500000.0 nM -
CHEMBL255008 — IC50 >= 500000.0 nM -
CHEMBL255008 — MIC90 >= 500000.0 nM -
CHEMBL255435 — IC50 >= 500000.0 nM -
CHEMBL255435 — MIC90 >= 500000.0 nM -
CHEMBL427902 — IC50 >= 500000.0 nM -
CHEMBL257397 — MIC90 = 125000.0 nM -
CHEMBL258378 — MIC90 = 125000.0 nM -
CHEMBL256128 — IC50 = 125000.0 nM -
CHEMBL256128 — MIC90 > 250000.0 nM -
CHEMBL258166 — MIC90 = 125000.0 nM -
CHEMBL258440 — MIC90 = 125000.0 nM -
CHEMBL255241 — MIC90 = 125000.0 nM -
CHEMBL257608 — IC50 = 167000.0 nM -
CHEMBL404040 — MIC90 = 167000.0 nM -
CHEMBL404731 — MIC90 = 63000.0 nM -
CHEMBL374478 RIFAMPIN MIC90 = 8.0 nM -
CHEMBL257608 — MIC90 > 250000.0 nM -
CHEMBL256309 — IC50 = 101000.0 nM -
CHEMBL256309 — MIC90 = 417000.0 nM -
CHEMBL255234 — MIC90 = 63000.0 nM -
CHEMBL402834 — MIC90 = 13000.0 nM -
CHEMBL256080 — MIC90 = 63000.0 nM -
CHEMBL256079 — MIC90 = 104000.0 nM -