Assay Detail
Binding
CHEMBL932635
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Inhibition of PKBbeta recombinant by radiometric filter binding assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.83 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409503 | — | — | 1 | 8.52 |
| CHEMBL260000 | — | — | 1 | 8.30 |
| CHEMBL263664 | — | — | 1 | 8.22 |
| CHEMBL407504 | — | — | 1 | 8.15 |
| CHEMBL259998 | — | — | 1 | 8.15 |
| CHEMBL406863 | — | — | 1 | 8.10 |
| CHEMBL260577 | — | — | 1 | 7.92 |
| CHEMBL260358 | — | — | 1 | 7.80 |
| CHEMBL228133 | — | — | 1 | 7.70 |
| CHEMBL259999 | — | — | 1 | 7.60 |
| CHEMBL405384 | — | — | 1 | 7.60 |
| CHEMBL260463 | — | — | 1 | 7.60 |
| CHEMBL261034 | — | — | 1 | 7.15 |
| CHEMBL259141 | — | — | 1 | 6.75 |
| CHEMBL261247 | — | — | 1 | 6.61 |
| CHEMBL261260 | — | — | 1 | 6.57 |
| CHEMBL259356 | — | — | 1 | 6.54 |
| CHEMBL104264 | — | — | 1 | 6.23 |
| CHEMBL261249 | — | — | 1 | 6.11 |
| CHEMBL265451 | — | — | 1 | 6.08 |
| CHEMBL264965 | — | — | 1 | 6.06 |
| CHEMBL265193 | — | — | 1 | 6.04 |
| CHEMBL376388 | — | — | 1 | 5.16 |
| CHEMBL264667 | — | — | 1 | 4.39 |
| CHEMBL264666 | — | — | 1 | 4.23 |
| CHEMBL265194 | — | — | 1 | 3.96 |
| CHEMBL389685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409503 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL260000 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL263664 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL407504 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL259998 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL406863 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL260577 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL260358 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL228133 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL259999 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL405384 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL260463 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL261034 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL259141 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL261247 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL261260 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL259356 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL104264 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL261249 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL265451 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL264965 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL265193 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL376388 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL264667 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL264666 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL265194 | — | IC50 | = | 110000.0 | nM | 3.96 |
| CHEMBL389685 | — | IC50 | > | 100000.0 | nM | - |