Compound Detail
CHEMBL265194
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Basic Information
| ChEMBL ID | CHEMBL265194 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VNNDRKUYJKCTAU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
232.3
MW (Da)
0.59
ALogP
5
HBA
2
HBD
83.7
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 3.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | IC50 | 3.96 | 3.96 | 110000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-beta serine/threonine-protein kinase | IC50 | = | 110000.0 | nM | 3.96 | Inhibition of PKBbeta recombinant by radiometric filter binding assay | 18345609 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18345609 | 10.1021/jm701437d | RAC-beta serine/threonine-protein kinase | 1 |
| 18345609 | 10.1021/jm701437d | Unchecked | 1 |
| 18345609 | 10.1021/jm701437d | NON-PROTEIN TARGET | 1 |
| 18345609 | 10.1021/jm701437d | Glycogen synthase kinase-3 beta | 1 |
Data from ChEMBL 36 via Core Engine