Assay Detail
Binding
CHEMBL932636
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Inhibition of recombinant catalytic subunit PKA by radiometric filter binding assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.91 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260358 | — | — | 1 | 8.52 |
| CHEMBL260463 | — | — | 1 | 8.52 |
| CHEMBL260577 | — | — | 1 | 8.52 |
| CHEMBL406863 | — | — | 1 | 8.30 |
| CHEMBL409503 | — | — | 1 | 8.15 |
| CHEMBL260000 | — | — | 1 | 8.05 |
| CHEMBL259998 | — | — | 1 | 7.82 |
| CHEMBL407504 | — | — | 1 | 7.64 |
| CHEMBL261034 | — | — | 1 | 7.57 |
| CHEMBL405384 | — | — | 1 | 7.27 |
| CHEMBL263664 | — | — | 1 | 6.78 |
| CHEMBL259999 | — | — | 1 | 6.54 |
| CHEMBL261249 | — | — | 1 | 6.34 |
| CHEMBL261247 | — | — | 1 | 6.14 |
| CHEMBL259356 | — | — | 1 | 6.05 |
| CHEMBL259141 | — | — | 1 | 5.81 |
| CHEMBL264965 | — | — | 1 | 5.71 |
| CHEMBL265193 | — | — | 1 | 5.62 |
| CHEMBL261260 | — | — | 1 | 5.39 |
| CHEMBL104264 | — | — | 1 | 5.28 |
| CHEMBL265451 | — | — | 1 | 5.14 |
| CHEMBL264667 | — | — | 1 | - |
| CHEMBL265194 | — | — | 1 | - |
| CHEMBL264666 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260358 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL260463 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL260577 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL406863 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL409503 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL260000 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL259998 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL407504 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL261034 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL405384 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL263664 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL259999 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL261249 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL261247 | — | IC50 | = | 726.0 | nM | 6.14 |
| CHEMBL259356 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL259141 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL264965 | — | IC50 | = | 1933.0 | nM | 5.71 |
| CHEMBL265193 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL261260 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL104264 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL265451 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL264667 | — | IC50 | - | — | - | |
| CHEMBL265194 | — | IC50 | - | — | - | |
| CHEMBL264666 | — | IC50 | - | — | - |