Assay Detail
Functional
CHEMBL932640
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Growth inhibition of human U87MG cells by SRB assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.40 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406863 | — | — | 1 | 6.28 |
| CHEMBL260577 | — | — | 1 | 5.46 |
| CHEMBL260000 | — | — | 1 | 5.37 |
| CHEMBL259998 | — | — | 1 | 5.33 |
| CHEMBL263664 | — | — | 1 | 5.30 |
| CHEMBL405384 | — | — | 1 | 5.22 |
| CHEMBL104264 | — | — | 1 | 4.82 |
| CHEMBL261247 | — | — | 1 | - |
| CHEMBL259999 | — | — | 1 | - |
| CHEMBL407504 | — | — | 1 | - |
| CHEMBL409503 | — | — | 1 | - |
| CHEMBL260463 | — | — | 1 | - |
| CHEMBL260358 | — | — | 1 | - |
| CHEMBL261034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406863 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL260577 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL260000 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL259998 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL263664 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL405384 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL104264 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL261247 | — | IC50 | - | — | - | |
| CHEMBL259999 | — | IC50 | - | — | - | |
| CHEMBL407504 | — | IC50 | - | — | - | |
| CHEMBL409503 | — | IC50 | - | — | - | |
| CHEMBL260463 | — | IC50 | - | — | - | |
| CHEMBL260358 | — | IC50 | - | — | - | |
| CHEMBL261034 | — | IC50 | - | — | - |