Assay Detail
Functional
CHEMBL932797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 in MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.64 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408699 | — | — | 1 | 9.05 |
| CHEMBL273128 | — | — | 1 | 8.15 |
| CHEMBL203443 | — | — | 1 | 7.77 |
| CHEMBL379664 | — | — | 1 | 7.12 |
| CHEMBL270717 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408699 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL273128 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL203443 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL379664 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL270717 | — | EC50 | = | 805.0 | nM | 6.09 |