Assay Detail
Functional
CHEMBL932835
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Inhibition of VEGF-induced proliferation of HUVEC cells
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.93 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409538 | — | — | 1 | 9.40 |
| CHEMBL272824 | — | — | 1 | 9.10 |
| CHEMBL272198 | — | — | 1 | 9.00 |
| CHEMBL429585 | — | — | 1 | 8.70 |
| CHEMBL272823 | — | — | 1 | 8.70 |
| CHEMBL410841 | — | — | 1 | 8.70 |
| CHEMBL411091 | — | — | 1 | 8.70 |
| CHEMBL269915 | — | — | 1 | 8.70 |
| CHEMBL272691 | — | — | 1 | 8.70 |
| CHEMBL272693 | — | — | 1 | 8.70 |
| CHEMBL406388 | — | — | 1 | 8.70 |
| CHEMBL409512 | — | — | 1 | 8.52 |
| CHEMBL412291 | — | — | 1 | 8.52 |
| CHEMBL408211 | — | — | 1 | 8.40 |
| CHEMBL270092 | — | — | 1 | 8.29 |
| CHEMBL259461 | — | — | 1 | 8.22 |
| CHEMBL259252 | — | — | 1 | 8.15 |
| CHEMBL409103 | — | — | 1 | 8.15 |
| CHEMBL410903 | — | — | 1 | 8.15 |
| CHEMBL270547 | — | — | 1 | 8.15 |
| CHEMBL270978 | — | — | 1 | 8.15 |
| CHEMBL273062 | — | — | 1 | 8.10 |
| CHEMBL429743 | — | — | 1 | 8.10 |
| CHEMBL270745 | — | — | 1 | 8.00 |
| CHEMBL270277 | — | — | 1 | 7.85 |
| CHEMBL270983 | — | — | 1 | 7.85 |
| CHEMBL270985 | — | — | 1 | 7.80 |
| CHEMBL269916 | — | — | 1 | 7.55 |
| CHEMBL273064 | — | — | 1 | 7.47 |
| CHEMBL271563 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409538 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL272824 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL272198 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL429585 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL272823 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL410841 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL411091 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL269915 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL272691 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL272693 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL406388 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL412291 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL409512 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL408211 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL270092 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL259461 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL259252 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL409103 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL410903 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL270547 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL270978 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL429743 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL273062 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL270745 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL270277 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL270983 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL270985 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL269916 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL273064 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL271563 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL410093 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL407715 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL408478 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL272449 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL428961 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL272670 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL272827 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL446367 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL271181 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL269891 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL269914 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL413933 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL271414 | — | IC50 | - | — | - | |
| CHEMBL270258 | — | IC50 | - | — | - |