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Assay Detail

CHEMBL932836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of bFGF-induced proliferation of HUVEC cells
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HUVEC
Confidence 1 — Organism
Curated By Autocuration

Target

HUVEC (CHEMBL613979) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
Harmange JC, Weiss MM, Germain J, Polverino AJ, Borg G, Bready J, Chen D, Choquette D, Coxon A, DeMelfi T, DiPietro L, Doerr N, Estrada J, Flynn J, Graceffa RF, Harriman SP, Kaufman S, La DS, Long A, Martin MW, Neervannan S, Patel VF, Potashman M, Regal K, Roveto PM, Schrag ML, Starnes C, Tasker A, Teffera Y, Wang L, White RD, Whittington DA, Zanon R.
J Med Chem (2008) 51 : 1649 -1667
PubMed 18324761 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 6.50 7.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL270745 — — 1 7.06
CHEMBL270277 — — 1 6.94
CHEMBL272198 — — 1 6.78
CHEMBL408478 — — 1 6.72
CHEMBL271563 — — 1 6.69
CHEMBL270985 — — 1 6.64
CHEMBL269914 — — 1 6.64
CHEMBL259461 — — 1 6.60
CHEMBL429585 — — 1 6.55
CHEMBL269915 — — 1 6.54
CHEMBL410841 — — 1 6.52
CHEMBL409512 — — 1 6.42
CHEMBL411091 — — 1 6.26
CHEMBL272824 — — 1 6.24
CHEMBL272691 — — 1 6.22
CHEMBL269916 — — 1 6.13
CHEMBL407715 — — 1 6.03
CHEMBL406388 — — 1 5.96
CHEMBL446367 — — 1 -
CHEMBL429743 — — 1 -
CHEMBL273062 — — 1 -
CHEMBL273064 — — 1 -
CHEMBL410093 — — 1 -
CHEMBL272670 — — 1 -
CHEMBL270092 — — 1 -
CHEMBL269891 — — 1 -
CHEMBL413933 — — 1 -
CHEMBL271414 — — 1 -
CHEMBL270258 — — 1 -
CHEMBL272827 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL270745 — IC50 = 88.0 nM 7.06
CHEMBL270277 — IC50 = 115.0 nM 6.94
CHEMBL272198 — IC50 = 167.0 nM 6.78
CHEMBL408478 — IC50 = 190.0 nM 6.72
CHEMBL271563 — IC50 = 205.0 nM 6.69
CHEMBL270985 — IC50 = 228.0 nM 6.64
CHEMBL269914 — IC50 = 228.0 nM 6.64
CHEMBL259461 — IC50 = 250.0 nM 6.60
CHEMBL429585 — IC50 = 280.0 nM 6.55
CHEMBL269915 — IC50 = 286.0 nM 6.54
CHEMBL410841 — IC50 = 305.0 nM 6.52
CHEMBL409512 — IC50 = 380.0 nM 6.42
CHEMBL411091 — IC50 = 548.0 nM 6.26
CHEMBL272824 — IC50 = 577.0 nM 6.24
CHEMBL272691 — IC50 = 605.0 nM 6.22
CHEMBL269916 — IC50 = 742.0 nM 6.13
CHEMBL407715 — IC50 = 944.0 nM 6.03
CHEMBL406388 — IC50 = 1100.0 nM 5.96
CHEMBL408211 — IC50 > 1140.0 nM -
CHEMBL409103 — IC50 > 1140.0 nM -
CHEMBL410903 — IC50 > 1140.0 nM -
CHEMBL259252 — IC50 > 1140.0 nM -
CHEMBL428961 — IC50 - — -
CHEMBL270978 — IC50 > 1140.0 nM -
CHEMBL409538 — IC50 - — -
CHEMBL272693 — IC50 > 1140.0 nM -
CHEMBL270983 — IC50 > 1140.0 nM -
CHEMBL271181 — IC50 > 1100.0 nM -
CHEMBL412291 — IC50 - — -
CHEMBL270547 — IC50 > 1140.0 nM -
CHEMBL272823 — IC50 > 1100.0 nM -
CHEMBL272449 — IC50 > 1100.0 nM -
CHEMBL272827 — IC50 > 1100.0 nM -
CHEMBL270258 — IC50 - — -
CHEMBL271414 — IC50 - — -
CHEMBL413933 — IC50 > 1100.0 nM -
CHEMBL269891 — IC50 > 1100.0 nM -
CHEMBL270092 — IC50 - — -
CHEMBL272670 — IC50 > 1100.0 nM -
CHEMBL410093 — IC50 > 1140.0 nM -
CHEMBL273064 — IC50 > 1100.0 nM -
CHEMBL273062 — IC50 > 1100.0 nM -
CHEMBL429743 — IC50 > 1100.0 nM -
CHEMBL446367 — IC50 > 1140.0 nM -