Assay Detail
Functional
CHEMBL932920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant CB2 receptor expressed in HEK cells assessed as calcium mobilization by FLIPR
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 54 | 7.28 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271158 | — | — | 1 | 8.15 |
| CHEMBL270955 | — | — | 1 | 8.15 |
| CHEMBL259462 | — | — | 1 | 8.00 |
| CHEMBL411674 | — | — | 1 | 8.00 |
| CHEMBL262865 | — | — | 1 | 7.85 |
| CHEMBL409491 | — | — | 1 | 7.82 |
| CHEMBL272868 | — | — | 1 | 7.75 |
| CHEMBL272176 | — | — | 1 | 7.68 |
| CHEMBL410677 | — | — | 1 | 7.66 |
| CHEMBL409669 | — | — | 1 | 7.43 |
| CHEMBL406399 | — | — | 1 | 7.39 |
| CHEMBL410655 | — | — | 1 | 7.35 |
| CHEMBL271814 | — | — | 1 | 7.30 |
| CHEMBL272882 | — | — | 1 | 7.21 |
| CHEMBL259253 | — | — | 1 | 7.19 |
| CHEMBL410313 | — | — | 1 | 7.14 |
| CHEMBL408964 | — | — | 1 | 7.09 |
| CHEMBL188 | WIN-552122 | — | 1 | 7.07 |
| CHEMBL410676 | — | — | 1 | 7.04 |
| CHEMBL270546 | — | — | 1 | 6.87 |
| CHEMBL271837 | — | — | 1 | 6.73 |
| CHEMBL409647 | — | — | 1 | 6.65 |
| CHEMBL1203961 | — | — | 1 | 6.64 |
| CHEMBL259463 | — | — | 1 | 6.55 |
| CHEMBL410842 | — | — | 1 | 6.42 |
| CHEMBL306764 | — | — | 1 | 6.20 |
| CHEMBL409537 | — | — | 1 | - |
| CHEMBL411244 | — | — | 1 | - |
| CHEMBL408430 | — | — | 1 | - |
| CHEMBL271810 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271158 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL270955 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL411674 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL259462 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL262865 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL409491 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL272868 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL272176 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL410677 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL409669 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL406399 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL410655 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL271814 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL272882 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL259253 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL410313 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL408964 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL188 | WIN-552122 | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL410676 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL270546 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL271837 | — | EC50 | = | 186.0 | nM | 6.73 |
| CHEMBL409647 | — | EC50 | = | 226.0 | nM | 6.65 |
| CHEMBL1203961 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL259463 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL410842 | — | EC50 | = | 383.0 | nM | 6.42 |
| CHEMBL306764 | — | EC50 | = | 634.0 | nM | 6.20 |
| CHEMBL271527 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL409265 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL272876 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL406918 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL411631 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL269851 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL411937 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL411888 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL270082 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL408174 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL411673 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL272659 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL409537 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL410441 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL271839 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL271838 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL272658 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL271553 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL271805 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL272189 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL270968 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL271810 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL408430 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL411244 | — | EC50 | > | 10000.0 | nM | - |