Assay Detail
Binding
CHEMBL933047
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Inhibition of HIV1 protease expressed in Escherichia coli
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.15 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.28 |
| CHEMBL405316 | — | — | 1 | 8.64 |
| CHEMBL442805 | — | — | 1 | 8.64 |
| CHEMBL272832 | — | — | 1 | 8.62 |
| CHEMBL270059 | — | — | 1 | 8.62 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.57 |
| CHEMBL270135 | — | — | 1 | 8.55 |
| CHEMBL539678 | — | — | 1 | 8.55 |
| CHEMBL271818 | — | — | 1 | 8.54 |
| CHEMBL259895 | — | — | 1 | 8.48 |
| CHEMBL429609 | — | — | 1 | 8.48 |
| CHEMBL405041 | — | — | 1 | 8.47 |
| CHEMBL405858 | — | — | 1 | 8.46 |
| CHEMBL406420 | — | — | 1 | 8.44 |
| CHEMBL405019 | — | — | 1 | 8.44 |
| CHEMBL269874 | — | — | 1 | 8.44 |
| CHEMBL272849 | — | — | 1 | 8.35 |
| CHEMBL273031 | — | — | 1 | 8.31 |
| CHEMBL273057 | — | — | 1 | 8.30 |
| CHEMBL272848 | — | — | 1 | 8.26 |
| CHEMBL259884 | — | — | 1 | 8.24 |
| CHEMBL442971 | — | — | 1 | 8.17 |
| CHEMBL437606 | — | — | 1 | 8.17 |
| CHEMBL271756 | — | — | 1 | 8.14 |
| CHEMBL407748 | — | — | 1 | 8.00 |
| CHEMBL270080 | — | — | 1 | 7.96 |
| CHEMBL405092 | — | — | 1 | 7.62 |
| CHEMBL438010 | — | — | 1 | 6.92 |
| CHEMBL405313 | — | — | 1 | 6.72 |
| CHEMBL259039 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL405316 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL442805 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL272832 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL270059 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1163 | ATAZANAVIR | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL270135 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL539678 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL271818 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL259895 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL429609 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL405041 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL405858 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL406420 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL269874 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL405019 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL272849 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL273031 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL273057 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL272848 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL259884 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL437606 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL442971 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL271756 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL407748 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL270080 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL405092 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL438010 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL405313 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL259039 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL436861 | — | Ki | = | 980.0 | nM | 6.01 |