Compound Detail
CHEMBL405313
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COC(=O)N[C@H](C(=O)NN(CCC[C@](Cc1ccccc1)(O[Si](C)(C)C(C)(C)C)C(=O)N[C@H]1c2ccccc2C[C@H]1O)Cc1ccc(Br)cc1)C(C)(C)C
Basic Information
| ChEMBL ID | CHEMBL405313 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LIPFOEZBIBFSHB-UATCYUFCSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
824.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protease CHEMBL2366517 | Ki | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protease | Ki | = | 190.0 | nM | 6.72 | Inhibition of HIV1 protease expressed in Escherichia coli | 18215014 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18215014 | 10.1021/jm070680h | Protease | 1 |
| 18215014 | 10.1021/jm070680h | Human immunodeficiency virus 1 | 1 |
| 18215014 | 10.1021/jm070680h | MT4 | 1 |
Data from ChEMBL 36 via Core Engine