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Assay Detail

CHEMBL933439

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human factor 10a
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Coagulation factor X (CHEMBL244) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sulfonamidolactam inhibitors of coagulation factor Xa.
Smallheer JM, Wang S, Laws ML, Nakajima S, Hu Z, Han W, Jacobson I, Luettgen JM, Rossi KA, Rendina AR, Knabb RM, Wexler RR, Lam PY, Quan ML.
Bioorg Med Chem Lett (2008) 18 : 2428 -2433
PubMed 18329876 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 53 8.16 10.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL270221 — — 1 10.89
CHEMBL401958 — — 1 10.80
CHEMBL256451 — — 1 10.70
CHEMBL270862 — — 1 10.70
CHEMBL270034 — — 1 10.43
CHEMBL258274 — — 1 10.37
CHEMBL269955 — — 1 10.30
CHEMBL256820 — — 1 10.00
CHEMBL271904 — — 1 9.96
CHEMBL442457 — — 1 9.89
CHEMBL401788 — — 1 9.68
CHEMBL404119 — — 1 9.46
CHEMBL402828 — — 1 9.37
CHEMBL272136 — — 1 9.15
CHEMBL256628 — — 1 9.08
CHEMBL408044 — — 1 9.06
CHEMBL271427 — — 1 9.00
CHEMBL270829 — — 1 8.96
CHEMBL270565 — — 1 8.77
CHEMBL270255 — — 1 8.66
CHEMBL403106 — — 1 8.66
CHEMBL256890 — — 1 8.64
CHEMBL272349 — — 1 8.62
CHEMBL257854 — — 1 8.57
CHEMBL402064 — — 1 8.28
CHEMBL257037 — — 1 8.00
CHEMBL429741 — — 1 7.80
CHEMBL402237 — — 1 7.75
CHEMBL429758 — — 1 7.72
CHEMBL255799 — — 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL270221 — Ki = 0.013 nM 10.89
CHEMBL401958 — Ki = 0.016 nM 10.80
CHEMBL270862 — Ki = 0.02 nM 10.70
CHEMBL256451 — Ki = 0.02 nM 10.70
CHEMBL270034 — Ki = 0.037 nM 10.43
CHEMBL258274 — Ki = 0.043 nM 10.37
CHEMBL269955 — Ki = 0.05 nM 10.30
CHEMBL256820 — Ki = 0.1 nM 10.00
CHEMBL271904 — Ki = 0.11 nM 9.96
CHEMBL442457 — Ki = 0.13 nM 9.89
CHEMBL401788 — Ki = 0.21 nM 9.68
CHEMBL404119 — Ki = 0.35 nM 9.46
CHEMBL402828 — Ki = 0.43 nM 9.37
CHEMBL272136 — Ki = 0.71 nM 9.15
CHEMBL256628 — Ki = 0.84 nM 9.08
CHEMBL408044 — Ki = 0.88 nM 9.06
CHEMBL271427 — Ki = 1.0 nM 9.00
CHEMBL270829 — Ki = 1.1 nM 8.96
CHEMBL270565 — Ki = 1.7 nM 8.77
CHEMBL270255 — Ki = 2.2 nM 8.66
CHEMBL403106 — Ki = 2.2 nM 8.66
CHEMBL256890 — Ki = 2.3 nM 8.64
CHEMBL272349 — Ki = 2.4 nM 8.62
CHEMBL257854 — Ki = 2.7 nM 8.57
CHEMBL402064 — Ki = 5.3 nM 8.28
CHEMBL257037 — Ki = 10.0 nM 8.00
CHEMBL429741 — Ki = 16.0 nM 7.80
CHEMBL402237 — Ki = 18.0 nM 7.75
CHEMBL429758 — Ki = 19.0 nM 7.72
CHEMBL255799 — Ki = 19.0 nM 7.72
CHEMBL272736 — Ki = 23.0 nM 7.64
CHEMBL272115 — Ki = 26.0 nM 7.58
CHEMBL403291 — Ki = 28.0 nM 7.55
CHEMBL257453 — Ki = 28.0 nM 7.55
CHEMBL272959 — Ki = 44.5 nM 7.35
CHEMBL272772 — Ki = 53.0 nM 7.28
CHEMBL402321 — Ki = 61.0 nM 7.21
CHEMBL257451 — Ki = 73.0 nM 7.14
CHEMBL272737 — Ki = 78.0 nM 7.11
CHEMBL257240 — Ki = 100.0 nM 7.00
CHEMBL442804 — Ki = 160.0 nM 6.80
CHEMBL256458 — Ki = 200.0 nM 6.70
CHEMBL409678 — Ki = 260.0 nM 6.58
CHEMBL272116 — Ki = 270.0 nM 6.57
CHEMBL257319 — Ki = 370.0 nM 6.43
CHEMBL257242 — Ki = 380.0 nM 6.42
CHEMBL257241 — Ki = 420.0 nM 6.38
CHEMBL272976 — Ki = 450.0 nM 6.35
CHEMBL272977 — Ki = 560.0 nM 6.25
CHEMBL402730 — Ki = 650.0 nM 6.19