Assay Detail
Binding
CHEMBL933567
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Binding affinity at human adenosine A2A receptor
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 7.46 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406315 | — | — | 1 | 8.89 |
| CHEMBL407307 | — | — | 1 | 8.85 |
| CHEMBL407650 | — | — | 1 | 8.80 |
| CHEMBL259323 | — | — | 1 | 8.68 |
| CHEMBL402464 | — | — | 1 | 8.64 |
| CHEMBL260718 | — | — | 1 | 8.55 |
| CHEMBL406049 | — | — | 1 | 8.51 |
| CHEMBL260719 | — | — | 1 | 8.48 |
| CHEMBL406048 | — | — | 1 | 8.44 |
| CHEMBL407064 | — | — | 1 | 8.24 |
| CHEMBL259442 | — | — | 1 | 8.18 |
| CHEMBL408624 | — | — | 1 | 7.92 |
| CHEMBL259337 | — | — | 1 | 7.89 |
| CHEMBL406314 | — | — | 1 | 7.85 |
| CHEMBL406298 | — | — | 1 | 7.85 |
| CHEMBL407638 | — | — | 1 | 7.75 |
| CHEMBL259952 | — | — | 1 | 7.72 |
| CHEMBL260773 | — | — | 1 | 7.70 |
| CHEMBL259953 | — | — | 1 | 7.58 |
| CHEMBL265695 | — | — | 1 | 7.52 |
| CHEMBL259111 | — | — | 1 | 7.46 |
| CHEMBL259445 | — | — | 1 | 7.40 |
| CHEMBL265696 | — | — | 1 | 7.26 |
| CHEMBL260667 | — | — | 1 | 7.24 |
| CHEMBL405567 | — | — | 1 | 7.22 |
| CHEMBL402817 | — | — | 1 | 7.16 |
| CHEMBL406483 | — | — | 1 | 7.09 |
| CHEMBL403704 | — | — | 1 | 6.85 |
| CHEMBL407327 | — | — | 1 | 6.81 |
| CHEMBL405479 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406315 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL407307 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL407650 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL259323 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL402464 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL260718 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL406049 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL260719 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL406048 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL407064 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL259442 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL408624 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL259337 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL406314 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL406298 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL407638 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL259952 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL260773 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL259953 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL265695 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL259111 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL259445 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL265696 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL260667 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL405567 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL402817 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL406483 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL403704 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL407327 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL405479 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL258900 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL408146 | — | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL253753 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL265937 | — | Ki | = | 444.0 | nM | 6.35 |
| CHEMBL259338 | — | Ki | = | 681.0 | nM | 6.17 |
| CHEMBL258901 | — | Ki | = | 748.0 | nM | 6.13 |
| CHEMBL407652 | — | Ki | = | 779.0 | nM | 6.11 |
| CHEMBL261754 | — | Ki | = | 1326.0 | nM | 5.88 |
| CHEMBL406745 | — | Ki | = | 3079.0 | nM | 5.51 |