Assay Detail
Binding
CHEMBL933669
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Inhibition of FMS
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based optimization of a potent class of arylamide FMS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.93 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438533 | — | — | 1 | 9.52 |
| CHEMBL402337 | — | — | 1 | 9.40 |
| CHEMBL254702 | — | — | 1 | 9.10 |
| CHEMBL257620 | — | — | 1 | 9.10 |
| CHEMBL255443 | — | — | 1 | 9.10 |
| CHEMBL257154 | — | — | 1 | 9.00 |
| CHEMBL252436 | — | — | 1 | 9.00 |
| CHEMBL256712 | — | — | 1 | 8.70 |
| CHEMBL261699 | — | — | 1 | 8.70 |
| CHEMBL402908 | — | — | 1 | 8.30 |
| CHEMBL256950 | — | — | 1 | 8.10 |
| CHEMBL258709 | — | — | 1 | 8.00 |
| CHEMBL255501 | — | — | 1 | 7.82 |
| CHEMBL430214 | — | — | 1 | 7.80 |
| CHEMBL265432 | — | — | 1 | 7.75 |
| CHEMBL411471 | — | — | 1 | 7.42 |
| CHEMBL408431 | — | — | 1 | 7.27 |
| CHEMBL257153 | — | — | 1 | 7.22 |
| CHEMBL427775 | — | — | 1 | 7.22 |
| CHEMBL429855 | — | — | 1 | 7.22 |
| CHEMBL258461 | — | — | 1 | 6.33 |
| CHEMBL258474 | — | — | 1 | 6.20 |
| CHEMBL258680 | — | — | 1 | 6.05 |
| CHEMBL265433 | — | — | 1 | 6.03 |
| CHEMBL258238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438533 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL402337 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL254702 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL257620 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL255443 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL257154 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL252436 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL256712 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL261699 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL402908 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL256950 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL258709 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL255501 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL430214 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL265432 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL411471 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL408431 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL257153 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL427775 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL429855 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL258461 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL258474 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL258680 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL265433 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL258238 | — | IC50 | > | 150.0 | nM | - |