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Assay Detail

CHEMBL933670

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ADMET
Antiproliferative activity against BMDM cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Cell Type BMDM
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Structure-based optimization of a potent class of arylamide FMS inhibitors.
Meegalla SK, Wall MJ, Chen J, Wilson KJ, Ballentine SK, Desjarlais RL, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Illig CR.
Bioorg Med Chem Lett (2008) 18 : 3632 -3637
PubMed 18495479 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 8.22 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL257154 1 9.00
CHEMBL252436 1 8.70
CHEMBL254702 1 8.70
CHEMBL402337 1 8.44
CHEMBL256712 1 8.10
CHEMBL256950 1 7.52
CHEMBL429855 1 7.10
CHEMBL258238 1 -
CHEMBL257153 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL257154 IC50 = 1.0 nM 9.00
CHEMBL252436 IC50 = 2.0 nM 8.70
CHEMBL254702 IC50 = 2.0 nM 8.70
CHEMBL402337 IC50 = 3.6 nM 8.44
CHEMBL256712 IC50 = 8.0 nM 8.10
CHEMBL256950 IC50 = 30.0 nM 7.52
CHEMBL429855 IC50 = 80.0 nM 7.10
CHEMBL258238 IC50 > 1000.0 nM -
CHEMBL257153 IC50 > 1000.0 nM -