Assay Detail
Binding
CHEMBL933672
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Inhibition of human cathepsin L
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.70 | 8.15 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263634 | — | — | 1 | 8.15 |
| CHEMBL258492 | — | — | 1 | 7.39 |
| CHEMBL259450 | — | — | 1 | 7.25 |
| CHEMBL259183 | — | — | 1 | 6.96 |
| CHEMBL259451 | — | — | 1 | 6.94 |
| CHEMBL406930 | — | — | 1 | 6.70 |
| CHEMBL263661 | — | — | 1 | 5.52 |
| CHEMBL430225 | — | — | 1 | 4.66 |
| CHEMBL428458 | — | — | 1 | - |
| CHEMBL258493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263634 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL258492 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL259450 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL259183 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL259451 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL406930 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL263661 | — | IC50 | = | 2998.0 | nM | 5.52 |
| CHEMBL430225 | — | IC50 | = | 21797.0 | nM | 4.66 |
| CHEMBL428458 | — | Activity | - | — | - | |
| CHEMBL258493 | — | Activity | - | — | - |