Assay Detail
Functional
CHEMBL933781
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Vasorelaxation activity in Sprague-Dawley rat aortic assessed as inhibition of phenylephrin-induced contraction
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Vasorelaxing alkaloids and flavonoids from Cassytha filiformis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.40 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464748 | DICENTRINE | — | 1 | 7.10 |
| CHEMBL254549 | CASSYTHINE | — | 1 | 7.05 |
| CHEMBL404684 | NEOLITSINE | — | 1 | 6.54 |
| CHEMBL404685 | CASSYTHIC ACID | — | 1 | 5.61 |
| CHEMBL258394 | NARCISSIN | — | 1 | 4.78 |
| CHEMBL254551 | — | — | 1 | 4.78 |
| CHEMBL234316 | — | — | 1 | 4.63 |
| CHEMBL224744 | — | — | 1 | 4.54 |
| CHEMBL403551 | ISOFILIFORMINE | — | 1 | 4.50 |
| CHEMBL402782 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464748 | DICENTRINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL254549 | CASSYTHINE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL404684 | NEOLITSINE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL404685 | CASSYTHIC ACID | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL258394 | NARCISSIN | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL254551 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL234316 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL224744 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL403551 | ISOFILIFORMINE | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL402782 | — | IC50 | = | 32800.0 | nM | 4.48 |